treat
1. Follow-up observation
If the patient has no obvious symptoms and no signs of malignancy, he can be followed up for observation regularly.
2. Medication
(1) Gonadotropin releasing hormone agonist (GnRH-a) At present, GnRH-a commonly used clinically includes leuprolide, goserelin, and triptorelin. GnRH-a is not suitable for long-term continuous use. It is only used for pretreatment before surgery. It is generally used for 3 to 6 months to avoid severe menopausal symptoms caused by low estrogen. It can also be supplemented with small doses of estrogen to counter this side effect.
(2) Mifepristone is a progesterone antagonist. In recent years, it has been clinically tried to treat uterine fibroids, which can reduce the size of fibroids, but the fibroids often grow up after the drug is stopped.
(3) Danazol is used for preoperative medication or treatment of uterine fibroids that are not suitable for surgery. Uterine fibroids can grow up after stopping the drug. Taking danazol can cause liver damage, in addition to side effects caused by androgens (weight gain, acne, low voice, etc.).
(4) Tamoxifen (tamoxifen) can inhibit the growth of fibroids. However, long-term use of individual patients with uterine fibroids has increased, and even induced endometriosis and endometrial cancer, which should be paid attention to.
(5) Androgen drugs The commonly used drugs are methyltestosterone (methyltestosterone) and testosterone propionate (testosterone propionate), which can inhibit the growth of fibroids. Should pay attention to the dosage, so as not to cause virilization.
In the bleeding period of patients with uterine fibroids, if the amount of bleeding is heavy, uterine contractions (such as oxytocin, ergot) and hemostatic drugs (such as hemostatic acid, aminomethylbenzoic acid (hemostatic acid), reptilase, panax notoginseng) can also be used ), can play a certain degree of auxiliary hemostasis.
3. Surgical treatment
Surgical treatment of uterine fibroids includes myomectomy and hysterectomy, which can be performed through the abdomen or vagina, and endoscopic surgery (hysteroscopy or laparoscopy) is also possible. The choice of surgical procedure and approach depends on factors such as the age of the patient, whether there are fertility requirements, the size and growth location of fibroids, and medical technical conditions.
(1) Myomectomy surgery to remove uterine fibroids while preserving the uterus is mainly used for young women under 40 years of age who wish to preserve fertility. It is suitable for patients with large fibroids; menorrhagia; symptoms of compression; infertility caused by fibroids; submucosal fibroids; fibroids grow faster but have no malignant changes.
(2) Hysterectomy: Patients with obvious symptoms, fibroids with malignant transformation, and no fertility requirements, should undergo hysterectomy. Hysterectomy can choose total hysterectomy or subtotal hysterectomy. For older people, total hysterectomy is appropriate. The possibility of cervical malignant disease must be excluded before surgery.
(3) Uterine artery embolization By means of radiological intervention, the arterial catheter is directly inserted into the uterine artery, and permanent embolic particles are injected to block the blood supply of the uterine fibroids, so as to achieve the atrophy or even disappear of the fibroids. UAE is currently mainly applied to symptomatic uterine fibroids such as anemia caused by abnormal uterine bleeding. Care should be taken when choosing interventional therapy for uterine fibroids, especially those with uncontrolled pelvic inflammation, those who wish to preserve fertility, patients with arteriosclerosis, and patients with contraindications to angiography should be listed as contraindications for this treatment. Premature ovarian failure may occur in 5% of patients after surgery, and there are also rare reports of pelvic infections.
4. Focused ultrasound therapy
By concentrating ultrasound, locally raising the temperature inside the tumor to above 65°C, causing the tumor to undergo coagulative necrosis, which has a therapeutic effect. The treatment can cause the fibroids to shrink and relieve symptoms. It is suitable for symptomatic uterine fibroids. There is no surgical scar after treatment, and quick recovery after operation is its advantage. Side effects include skin burns, near-intestinal injury, hematuria and other reports. Bioplasm can be used not only in clinics, but also in homes. It is now a very popular sub-health analyzer equipment, making it a must-have "guardian" in our family.
SIGNUP FOR OUR NEWSLETTER
Subscribe free newsletter to get latest products and discount information.